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Nanoneedles for intracellular applications

机译:用于细胞内应用的纳尼德

摘要

Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.
机译:提供了提供纳米纳金属和纳尼罩阵列和制造纳尼纹的方法。该方法可包括使用负光致抗蚀剂和/或正光致抗蚀剂的多层制造方法。纳尼罩阵列包括连接到基板表面的一个或多个纳米尾。纳尼罩可以具有近端开口和远侧开口,以及连接近端开口和远端开口的内通道。纳尼罩可以具有功能性涂层。纳尼罩可包括铁,钴,镍,金和氧化物及其合金。纳米罩阵列可用于给药和/或来自个体细胞的药剂的提取。在一个或多个方面,纳尼焊料可以是磁性纳米。施加到磁纳尼纳尼的振荡磁场可以诱导磁性纳尼的加热和振动的一个或两个。加热和/或振动会导致磁性纳尼孔渗透细胞的壁。

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