USE OF DISULFIRAM IN PREPARATION OF MEDICAMENT FOR PREVENTION AND TREATMENT OF DISEASES RELATED TO NLRP3 INFLAMMASOME

摘要

Disclosed is the use of disulfiram in the preparation of a medicament for the prevention and treatment of diseases related to NLRP3 inflammasome. It is found in the study that disulfiram can effectively inhibit the activation of the NLRP3 inflammasome and inhibit the maturation and secretion of inflammatory activation signal molecule Caspase-1 P20 and inflammatory cytokine IL-1β, thereby having good prevention and treatment effects on diseases related to the NLRP3 inflammasome, and especially having significant prevention and treatment effects on peritonitis and gouty arthritis.