11-(4-CHLOROPHENYL)-4-(2,3-DIHYDRO-1H-INDOLE-1-CARBONYL)-3,11-DIMETHYL-5,10,DIOXATRICYCLO7.4.0.0,2,6,TRIDECA-1,3,6,8-TETRAEN-13-ONE AND DERIVATIVES AS DESTABILIZER OF CRY1 FOR THE TREATMENT OF CIRCADIAN RHYTHM ASSOCIATED DISEASES AND DISORDERS

摘要

The present invention relates to 11-(4-chlorophenyl)-4-(2,3-dihydro-1H-indole-1-carbonyl)-3,11-dimethyl-5,10,dioxatricyclo[7.4.0.0,2,6,]trideca-1,3,6,8-tetraen-13-one compound and related derivatives. The compound of the invention is a CRY1-binding small molecule and also a destabilizer of CRY1, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm, including CRY1-mediated diseases such as cancer.