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ICD INDUCER-IDO INHIBITOR CONJUGATE, AND PREPARATION METHOD AND APPLICATION THEREOF
ICD INDUCER-IDO INHIBITOR CONJUGATE, AND PREPARATION METHOD AND APPLICATION THEREOF
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机译:ICD诱导物-ADO抑制剂缀合物及其制备方法和应用
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摘要
Provided are an ICD inducer-IDO inhibitor conjugate, and a preparation method and application thereof. The conjugate has a structural formula (I). The preparation method comprises: enabling NLG919 and succinic anhydride to undergo an esterification reaction to obtain NLG919-SA, and enabling the NLG919-SA and Dox to undergo an amidation reaction to obtain the ICD inducer-IDO inhibitor conjugate. An ICD inducer and an IDO inhibitor are delivered simultaneously in a conjugate mode, which is more convenient.
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