Anti CD3 antibody, activatable anti-CD3 antibody, multiple specific anti-CD3 antibody, multiple specific activatable anti-CD3 antibody, and their use

摘要

CDB ε An antibody that specifically binds the epsilon chain of CD3 and its antigen binding fragment are also provided.Anti-CD3 of the present disclosure ε Antibodies and their antigen binding fragments are labeled as CD3 on T cells ε Activation of T cells through involvement.That is, such antibodies operate, stimulate, activate, and / or enhance CD3 mediated T cell activation.Their antibodies and their antigen binding fragments are ε This specification is referred to herein as an antibody or an anti-CD3 antibody.Anti CD 3 of the present disclosure ε Antibodies and their antigen binding fragments include monoclonal antibodies, such as mammalian monoclonal antibodies, primate monoclonal antibodies, complete human monoclonal antibodies, and humanized monoclonal antibodies and chimeric antibodies and their antigen binding fragments.Diagram