Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling

摘要

This invention provides a fusion protein, the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of amino acids in:(a) an extracellular domain of a human Notch1 receptor protein, followed by(b) an Fc portion of an antibody,wherein the extracellular domain of the human Notch1 receptor protein (i) commences with the amino acid present at the N-terminus of EGF-like repeat 10 and(ii) extends to and includes the C-terminal amino acid of EGF-like repeat 18 or 20.;Also provided is a composition comprising the any of the fusion proteins of this invention and a pharmaceutically acceptable carrier, a method of treating a subject suffering from age-related macular degeneration (AMD), diabetic retinopathy, or cancer which comprises administering to the subject any of the compositions of this invention in an amount effective to treat the subject's cancer.