OPTIMISATION OF COMBINATION DRUG THERAPIES

摘要

A method of optimising a combination drug therapy comprises: receiving, by at least one processor, exposure data indicative of measurements of a sample of a subject to whom two or more drugs have been administered at an initial dosing regimen, the measurements being of exposure levels of the two or more drugs at a plurality of time points; receiving, by the at least one processor, response data indicative of measurements of a therapeutic outcome variable at the plurality of time points; determining, using the at least one processor, from the response data and the exposure data, a response function that relates the therapeutic outcome to the exposure levels of the two or more drugs; optimising, using the at least one processor, the response function with respect to the exposure levels to determine optimised exposure levels for the subject; and generating, using the at least one processor, an optimised dosing regimen based on the optimised exposure levels.