Markers useful in reinforcement strategies for the treatment of osteoarthritis

摘要

The present invention relates to pharmacogenetics, more specifically to strategies involving biomarkers associated with clinical responses to compounds before or during treatment of cartilage disorders such as osteoarthritis. The present invention more particularly relates to the combination of JSW measurements and the levels of specific proteins present in blood, serum, synovial fluid or urine, which may be used in prior or during treatment strategies such as patient enhancement in clinical trials, patient selection strategies, or It can be used to adapt the treatment of a patient in a treatment frame for cartilage disorders such as osteoarthritis.