Nephrotoxicity is the most known side effect of gentamicin, antibiotic which is widely used to treat Gram-negative infections. Probably reactive oxygen species (ROS) are responsible for gentamicin induced nephrotoxicity. In addition, RAS plays an important role in the pathogenesis of renal injury, and nephrotoxicity. Hypo magnesium is other complication of gentamicin. Therefore, considering the antioxidant effects of losartan and MgSO4 in recent studies, we made new generation of drug. This drug contains gentamicin as antibiotic plus losartan and MgSO4 as adjuvant to reduce gentamicin nephrotoxicity especially in hypertensive patients. On the other-hand we suggest prescription of gentamicin with MgSO4 and lower dosage of losartan for maximum nephroprotective effects in hospitalized patients.
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