A novel CAR construct comprising the TNFR2 domain

摘要

The present invention is a chimeric antigen receptor (CAR) comprising a human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or a human TNFR2 co-stimulatory intracellular signaling domain or a fragment or variant thereof, and expressing the CAR. It concerns immune cells. The present invention further provides an immune cell expressing a chimeric antigen receptor (CAR) comprising a human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or a human TNFR2 co-stimulatory intracellular signaling domain or a fragment or variant thereof. It relates to a method of treatment comprising the administration of.