3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of IKAROS family zinc finger 2 (IKZF2) dependent diseases

摘要

The present disclosure relates to compounds of formula I': [Formula I'] Or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof (in the formula R a , R b , R x , R i , R 2 , X 2 , and q are defined herein As described above), methods of manufacture and use thereof in treatment or disorders associated with a decrease in IKZF2 protein levels.