NANOPARTICLE DELIVERY SYSTEM FOR DISEASES ASSOCIATED WITH MAJOR BASEMENT MEMBRANE COMPONENTS OF BLOOD VESSELS ACCESSIBLE FROM BLOOD STREAM

摘要

A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.