首页> 外国专利> 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS

机译:2,5-二取代的3-甲基吡嗪和2,5,6-三取代的3-甲基吡嗪作为颠覆性SHP2抑制剂

摘要

The present disclosure is directed to inhibitors of SHP2, such as pyrazine compounds, and their use in the treatment of disease associated with SHP2 modulation, such as Noonan Syndrome, Leopard Syndrome, juvenile myelomonocytic leukemias, neuroblastoma, melanoma, acute myeloid leukemia and cancers of the breast, lung and colon. Also disclosed are pharmaceutical compositions comprising the same.
机译:本公开涉及SHP2的抑制剂,例如吡嗪化合物,以及它们在与SHP2调节相关的疾病的治疗中的用途,例如Noonan综合征,豹综合征,青少年骨髓细胞白血病,神经母细胞瘤,黑素瘤,急性髓性白血病和癌症乳房,肺和结肠。还公开了包含该药物组合物。

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