method for obtaining and manufacture of new derivatives of the fusidinsaeure and 24, 25 dihydrofusidinsaeure

• 1. 敏诺西迪供用于抑制与雄性素受体有关的功能的用途 [P] . 中国专利： CN105209045B . 2021.05.18
• 2. 敏诺西迪供用于抑制与雄性素受体有关的功能的用途 [P] . 中国专利： CN113134001A . 2021-07-20
• 3. A method for the production or production of new derivatives of the fusidic and the 24, 25 - dihydrofusidinsaeure [P] . 德国专利： DE1253706B . 1967-11-09

  机译： 一种生产或生产夫西地克和24，25-二氢夫西啶苷的新衍生物的方法

• 4. Method of obtaining 24(R),25- and 24(S),25-dihydroxy derivatives cholecalciferol [P] . PL192708B1 . 2006-12-29

  机译： 获得24（R），25-和24（S），25-二羟基衍生物胆钙化醇的方法

• 5. METHOD OF OBTAINING 24(R),25- AND 24(S),25-DIHYDROXY DERIVATIVES CHOLECALCIFEROL [P] . PL329101A1 . 2000-04-10

  机译： 获得24（R），25-和24（S），25-二羟基衍生物胆甾醇的方法

• 1. Methods for obtaining characteristic γ-ray net peak count from interlaced overlap peak in HPGe γ-ray spectrometer system [J] . Yue-Li Song, Feng-Qun Zhou, Yong Li, 核技术（英文版） . 2019,第001期
• 2. EFFICIENT METHOD FOR OBTAINING DERIVATIVES OF CURRENT VECTOR FOR AWE TECHNIQUES [C] . Maciej Surma MIKON Conference . 2006
• 3. The effects of 24R, 25-dihydroxyvitamin D3 and 24S, 25- dihydroxyvitamin D3 on phosphate transport in vivo. [D] . Meng, Yu. 2011
• 4. μ-1022-Dichloro-36-bis­(2-furylmeth­yl)-361418-tetra­azatricyclo­18.3.1.1812penta­cosa-1(23)81012(25)131820(24)21-octa­ene-2425-diolato-κ8 N 3N 6O 24O 25:N 14N 18O 24:O 25bis­chloridocopper(II) acetonitrile solvate [O] . Chen Chen, Yu Cheng, Pan Liu, 2009
• 5. Report drawn up on behalf of the Committee on Development and Cooperation on the proposals and communications from the Commission of the European Communities to the Council (Doc. 201/74) concerning the grant of generalized tariff preferences for 1975 on semi-manufactured products falling within Chapters 1-24 of the Common Customs Tariff and manufactured and semi-manufactured products falling within Chapters 25-99 of the Common customs Tariff originating in developing countries. Working Documents 1974-1975, Document 285/74, 14 October 1974 [O] . Kaspereit Gabriel 1974
• 6. Study on development of Saturn manufacturing technology for welding methods and techniques to reduce hydrogen porosity Final report, 25 Feb. - 24 Sep. 1966 [R] . Willhelm, A. C. 1966

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. 类镓等电子序列ZrⅩ-RhⅩⅤ离子的4s^24p-4s^24d、4s^24p-4s4p^2、4s^24p-4s^25s、4p^3-4s^25s以及4s4p^2-4p^3跃迁谱线和振子强度的理论计算 [J] . 蔡灵仓 ,李孝昌 . 光谱学与光谱分析 . 1998,第3期
• 3. Obtaining Bacteriocins by Chromatographic Methods [J] . Valery Borzenkov ,Vladimir Surovtsev ,Ivan Dyatlov . 生命科学与技术进展（英文） . 2014,第5期
• 4. Methods for obtaining CIR based on IFFT in MIMO-OFDMA mobile communication systems [J] . LU Xin ,WANG Jian-hua ,XU Jun . 通讯和计算机 . 2009,第002期
• 5. 新奥法在西迪阿里软岩隧道施工中的应用 [C] . 于维刚 . 中国铁道学会工程地质与路基专业委员会第21届年会暨学术交流会 . 2007
• 6. 格鲁克歌剧《奥菲欧与尤里迪西》中尤里迪西的音乐形象分析——以咏叹调《多么可怕的时刻》为例 [A] . 胡明哲 . 2020