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preparation process of new complexes of hydroxocobalamin and iodo aryl amino acid alkyl carboxylic acids
preparation process of new complexes of hydroxocobalamin and iodo aryl amino acid alkyl carboxylic acids
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机译:羟基钴胺素与碘代芳基氨基酸烷基羧酸新型配合物的制备方法
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摘要
The invention comprises hydroxocobalamine derivatives of formula A-CO-O-Co-R where A-CO- is derived from an iodo-aryl-aliphatic amino acid A-COOH, and -O-Co-R is derived from hydroxocobalamine HO-Co-R. In an example 3,5-di-iodo-tyrosine is reacted with hydroxocobalamine to obtain a derivative of the invention. Derivatives as above are used medicinally with pharmaceutically acceptable carriers as injectable or drinkable solutions, tablets, pills, suppositories and ointments, to treat anaemia, to stimulate the central nervous system, to stimulate basal metabolism and to lower cholesterolaemia. In examples, hydroxocobalamine 3,5-di-iodo-tyrosinate is dissolved in an aqueous buffer solution and is mixed with wheat starch, potato starch and magnesium stearate to form tablets.
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