Cpds. of formula (I): (where A is H, halogen, Sr2, OR2, N(R2)2, NHN(R2)2 or N3; R1 is CH2OH, alkyl or cycloalkyl (=6C), COOR2, furyl, tetrahydrofuryl, thienyl, an opt. unsatd. 5- or 6- membered ring contg. 1 or 2 atoms, or phenyl opt. substd. by one or more of R2, halogen, OR2, N(R2)2, OAc, NHAc or NO2, or by a single alkylenedroxy gp; R2 is H or 1-4C alkyl; Y is CH2, CH2CH2 or CH2CH2CH2; Ac is a =6C carboxylic acid residue; Z is a direct bond, CH2 or CH2CH2; the dotted line is an opt. bond) increase coronary circulation and/or the O2 partial pressure in coronary vascular blood, suppress intravascular pain, e.g. in angina pectoris, and have circulatory, lipolysis inhibiting and/or hypocholesterolaemic activity. They are also intermediates for other medicaments.
展开▼