A process for the preparation of nonapeptidos Peptide and used exclusively as a starting material in the procedure

摘要

1362743 Cyclic nonapeptides F HOFFMANN-LA ROCHE & CO AG 16 June 1972 [18 June 1971] 28339/72 Heading C2C Novel compounds I in which Q is Arg or Lys and their salts are prepared by conventional methods of peptide synthesis. Intermediates isolated are Z-leu-asp(NH 2 )- cys(B 2 ) - OMe; Z - leu - asp(NH 2 ) - cys(B 2 )- NHNH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - cys(B 2 ) - tyr - ileleu - asp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly- NH2; Z - ile - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - tyr(B 2 ) - ile - leuasp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly - NH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys(tosyl)- gly - NH 2 ; Z - ile - leu - asp(NH 2 ) - cys(B 2 )- pro - lys(tosyl) - gly - NH 2 ; and tosyl - cys(B 2 )- tyr - ile - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys- (tosyl)-gly-NH 2 . Pharmaceutical compositions comprise a compound I together with a suitable diluent and/or carrier and have natriuretic activity. They may be administered orally, rectally, nasally or parenterally.