improvement of the method for the preparation of a peptide with acth effect, zuuradditiezouten or complexes, method for preparation of pharmaceutical preparations.one or more of these compounds as the active substance, and objects obtained by application of the method.

摘要

Preparation of D-serlys17.18 beta-1-18 corticotropine lys18-amide (I) in which arginine in positions 17 and 18 of D-ser beta1-19 corticotropine are replaced by lysine; and also the corresponding derivative in which the glutamyl residue is replaced by glutamine. D-seryl, L-tyrosyl, L-seryl, L-methionyl, L-glutamyl, L-histidyl, L-phenylalanyl, L-arginyl, L-tryptophyl glycyl, L-lysyl, L-prolyl, L-valyl glycyl, L-lysyl, L-lysyl, L-lysyl, L-lysine The polypeptide is prepared by linking small groups of amino acids in which the amino acids are masked by t-butoxy-carbonyl groups and the carboxy groups by a t-butyl ester group, and then combining the larger units. Strong adrenocorticotropic activity.