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process for the production of the new 3 amp; beta; hydroxy 14, 15 amp; beta; - oxydo - 14 amp; beta; - bufa - 4,20,22 - trienolid, 3 amp; beta; - (amp; alpha; - l - rhamnopyranosids)
process for the production of the new 3 amp; beta; hydroxy 14, 15 amp; beta; - oxydo - 14 amp; beta; - bufa - 4,20,22 - trienolid, 3 amp; beta; - (amp; alpha; - l - rhamnopyranosids)
1315235 Bufapolyenolides FARBWERKE HOECHST AG 19 April 1971 [8 April 1970] 26359/71 Heading C2U The novel compound 3#-(-L-rhamnopyranosyloxy) - 14,15# - epoxy - 14# - bufa - 4,20,22- trienolide is prepared from proscillaridin by successively acylating the three sugar hydroxy groups, dehydrating in the 14,15-position, adding hypohalous acid acoross the resulting #SP14/SP- double bond, dehydrohalogenating the resulting 14#-hydroxy-15-halo grouping, and lastly liberating the three sugar hydroxy groups by saponification. The novel compound is stated to be cardioactive and may be made up with carriers into pharmaceutical compositions for oral administration.
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机译:1315235布法多烯内酯FARBWERKE HOECHST AG 1971年4月19日[1970年4月8日]标题C2U新型化合物3#-(-L-鼠李糖基吡喃烷氧基)-14,15#-环氧-14#-布法-4,20,22-三烯胺由普西拉地丁制备,方法是依次酰化三个糖羟基,在14,15-位脱水,加入次卤酸使所得的# 14 SP>-双键脱氢,使所得的14#-羟基-15脱卤化氢-卤基,最后通过皂化作用释放三个糖羟基。据称该新型化合物具有心脏活性,可以与载体一起制成药物组合物用于口服。
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