PROCESS FOR THE PRODUCTION OF BIS-CHROMONES

摘要

1,256,354. Bis-chromones. FISONS PHARMACEUTICALS Ltd. 22 April, 1969 [16 Feb., 1968], No. 7590/68. Heading C2C. Compounds of formula and their functional derivatives, are prepared by reacting a compound of formula with a compound of formula and where necessary converting the pairs of groups A 1 , As to -COCH=C(CO 2 H)-O- or a functional derivative thereof. In the formulµ, X is a carboxylic or heterocyclic ring, or an acyclic chain, which ring or chain may be interrupted by one or more heterocyclic or carbocyclic rings, by C=O, O, S, NH, or by substituted S or NH; P, Q, T, PSP1/SP, QSP1/SP, TSP1/SP are each H, halogen or optionally substituted alkyl or alkoxy; LSP1/SP, LSP2/SP are groups capable of forming an X group; the pair of groups ASP1/SP, ASP2/SP is (being not necessarily identical on each ring) OM and H or COJ, H and OCD=CHOO 2 RSP2/SP, OCOCORSP3/SP and H or COCH 3 , or together form the chain COCH=C(D)-O- or COCH 2 CH(D)-O-; M is H, alkali metal or C 1-6 alkyl; J is CH 3, ORSP2/SP, CH 2 COD or CH = CHD; RSP2/SP is H or C 1-10 alkyl, D is CO 2 RSP2/SP or a group convertible thereto and RSP3/SP is OH or a group convertible thereto. Details are given for the preparation of ethyl 5 - (2 - chloroethoxy)chromone - 2 - carboxylate and the iodoethoxy analogue.