Insulin derivatives which have an improved profile of hypoglycaemic activity, or which are intermediates for the production of such derivatives, are those in which at least one of the A1(glycine, B1(phenylalanine) and B29 (lysine) amino acid units is blocked by a carbamyl group or a substituted carbamyl group R1R2NCO- wherein R1 and R2 can be hydrogen, alkyl, aryl or other radicals.
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机译:具有降低的降血糖活性的胰岛素衍生物,或作为产生这种衍生物的中间体的胰岛素衍生物,是其中A1(甘氨酸,B1(苯丙氨酸)和B29(赖氨酸)氨基酸单元中的至少一个)被以下物质阻断的那些胰岛素衍生物:氨基甲酰基或取代的氨基甲酰基R 1 R 2 NCO-,其中R 1和R 2可以是氢,烷基,芳基或其他基团。
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