Description of an arrangement for determining the blood alcohol content by means of the measurement of the alcohol concentration in the alveolar breathing air

• 1. 血中酒精浓度上升抑制剂及血液酒精浓度上升抑制方法 [P] . 中国专利： CN103156879A . 2013-06-19
• 2. 确定血液酒精浓度超过一阈值水平的时刻的系统和方法 [P] . 中国专利： CN101317090B . 2012.03.21
• 3. A method and arrangement for the determination of the alcohol concentration of the blood by measurement of the alcohol concentration of the breathing air [P] . 德国专利： DE2906832A1 . 1980-08-28

  机译： 一种通过测量呼吸空气的酒精浓度来确定血液酒精浓度的方法和装置

• 4. A method and arrangement for the determination of the alcohol concentration of the blood by measurement of the alcohol concentration and the moisture in the breathing air [P] . 德国专利： DE2906790A1 . 1980-08-28

  机译： 一种通过测量呼吸空气中的酒精浓度和水分来确定血液中酒精浓度的方法和装置

• 5. Arrangement for the determination of the alcohol concentration of the blood by measurement of the alcohol concentration of the breathing air [P] . 德国专利： DE2428352C3 . 1978-09-28

  机译： 通过测量呼吸空气的酒精浓度来确定血液中酒精浓度的装置

• 1. To Investigate the Effect of Using Ethanol Containing Wipes in Collecting Blood for the Measurement of Alcohol Concentration [J] . Takami Nakao, Atsushi Nitta, Hiroshi Nishioka, 药理与制药（英文） . 2021,第010期
• 2. Changes in blood alcohol concentration and driving ability after alcohol intake [J] . 覃华丽, 张岫竹, 赵新才, 中国人民解放军军医大学学报（英文版） . 2004,第002期
• 3. Natural Compound Formula RM88 Significantly Reduces Blood Alcohol Concentration in Humans [J] . E. Russell Vickers 药理与制药（英文） . 2020,第006期
• 4. Determining blood and/or breath alcohol concentration from transdermal alcohol data [C] . Luczak, Susan E., Rosen, American Control Conference . 2013
• 5. Finite Dimensional Approximation and Convergence in the Estimation of theDistribution of, and Input to, Random Abstract Parabolic Systems withApplication to the Deconvolution of Blood/Breath Alcohol Concentration fromBiosensor Measured Transdermal Alcohol Level [D] . Sirlanci Tuysuzoglu, Melike. 2018
• 6. Comparison of spectroscopically measured tissue alcohol concentration to blood and breath alcohol measurements [O] . Trent D. Ridder, Benjamin J. Ver Steeg, Bentley D. Laaksonen 2009
• 7. Comparison of spectroscopically measured tissue alcohol concentration to blood and breath alcohol measurements [O] . Ridder, Trent D., Ver Steeg, Benjamin J., Laaksonen, Bentley D. 2009
• 8. General Deterrent Impact of California's 0.08% Blood Alcohol Concentration Limitand Administrative Per Se License Suspension Laws. Volume 1 of an Evaluation of the Effectiveness of California's 0.08% Blood Alcohol Concentration Limit and Administrative Pe [R] . 1995

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Individual Differences in Blood Alcohol Concentrations after Moderate Drinking Are Mainly Regulated by Gastric Emptying Rate Together with Ethanol Distribution Volume [J] . Shunji Oshima ,Takeshi Haseba ,Chiaki Masuda . 食品与营养科学（英文） . 2012,第6期
• 3. 靛酚蓝分光光度法测定空气中氨含量的测量不确定度评定 [C] . 顾淑英 . 第三届全国建筑材料测试技术交流会 . 2016
• 4. 人体血液中酒精浓度近红外光谱法无损检测及关键技术 [A] . 罗斯特 . 2013