2,4,5-TRISUBSTITUTED OXAZOLES AND PHARMACEUTICAL USES THEREOF

摘要

Pharmacologically active 2,4,5-trisubstituted oxazoles corresponding to the formula WHEREIN A represents cyclohexyl, 2-thienyl or a group represented by the formula WHEREIN R represents a p-phenyl group or one to three substituents selected from the group of hydrogen, hydroxy, lower alkyl, halo, halo-lower alkyl, nitro, cyano, amino, acetamino, carboxy, carbamyl, sulfamoyl and lower alkoxy; R1 and R3 are selected from the group of hydrogen, lower alkyl, lower alkenyl, cycloalkyl, phenyl, phenyl-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl, hydroxy, amino, lower alkylideneamino, cycloalkylideneamino, benzylideneamino; R2 and R4 are selected from the group of hydrogen, lower alkyl, lower alkenyl, cycloalkyl, phenyl, phenyl-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl; each of the pairs R1, R2 and R3, R4 may also form with the amino nitrogen atom a 5- to 7-membered heterocyclic ring which may contain one other heteroatom selected from N and O.