3,20-dioxo-7 alpha-acetylthio-21-hydroxy pregn-4-ene (I) adn 2,2-dimethyl-3,20-dioxo-21-propionyloxy-pregn-4-ene (I:Z is H, R1 is propionyloxy) are new. In (I) Z is acetylthio; R1 is OH; and in (II) Z is H; R is propionloxy. Used in treatment of arterial hypertension and cardiac insufficiently. The cpds are aldosterone antagonists and increase Na diuresis while maintaining organic K. In an example, (I) was prepd. from 3-oxo-20, 20-ethylene dioxy pregn-4-ene by methylation (CH3I), hydrolysis of the ketal, conversion of the 4,6-diene, with dichloro dicyano benzoquinone, acetoxylation at the 21-position with Pb tetraacetate and BF3 etherate, removal of the acetyl gp., and finally treatment with thioacetate acid.
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