首页> 外国专利> method for preparing from new derivatives of 2,6 - diphenyl - 3.7 - dioxabicyclo - 3,3,0 - by now - 4.8 - dion.these new derivatives and the application thereof as active ingredient in anti tumormidde len, catechol-o-methyl transferase inhibitors - methyltrans - and cyclic amp fosfodieester - inhibitors.

method for preparing from new derivatives of 2,6 - diphenyl - 3.7 - dioxabicyclo - 3,3,0 - by now - 4.8 - dion.these new derivatives and the application thereof as active ingredient in anti tumormidde len, catechol-o-methyl transferase inhibitors - methyltrans - and cyclic amp fosfodieester - inhibitors.

机译:制备2,6-二苯基-3.7-二恶双环-3,3,0-现在的新衍生物的方法-4.8-二酮。这些新衍生物及其作为抗肿瘤活性成分儿茶酚-邻-甲基的应用转移酶抑制剂-甲基反式-和环amp fosfodieester-抑制剂。

摘要

New derivatives of 2,6-diphenyl- 3,7-dioxabicyclo-[3,3,0]-octane-4,8- dione substituted on the phenyl rings have been found to have an anti-tumor, catechol-0-methyltransferase inhibitory and cyclic AMP phosphodiesterase inhibitory activity. The derivatives are prepared by subjecting cinnamic acid derivatives to an oxidative coupling reaction in the presence of an oxidizing agent.
机译:发现苯环上取代的2,6-二苯基-3,7-二氧杂双环-[3,3,0]-辛烷-4,8-​​二酮的新衍生物具有抗肿瘤儿茶酚-0-甲基转移酶抑制和环状AMP磷酸二酯酶的抑制活性。通过在氧化剂的存在下使肉桂酸衍生物进行氧化偶联反应来制备衍生物。

著录项

  • 公开/公告号NL7811308A

    专利类型

  • 公开/公告日1979-05-17

    原文格式PDF

  • 申请/专利号NL19780011308

  • 发明设计人

    申请日1978-11-15

  • 分类号C07D321/12;A61K31/335;

  • 国家 NL

  • 入库时间 2022-08-22 20:41:10

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