DERIVATIVES OF PYRAZOLO (3,4-B) THIENO (2,3-D) PYRIDINE-2-CARBOXYLIC ACIDS

摘要

AbstractNew derivatives of pyrazolo[3,4-b]thieno[2,3-d]-pyridine-2-carboxylic acids have the general formulawherein R and R2 each is hydrogen or lower alkyl; R1 ishydrogen, lower alkyl, phenyl or phenyl-lower alkyl; R3is lower alkyl, phenyl, substituted phenyl, hydroxy, loweralkoxy, , or , wherein thephenyl substituent is lower alkyl, halo, trifluoromethyl,amino or carboxy; R4 is hydrogen, lower alkyl or phenyl,R5 and R6 each is hydrogen or lower alkyl; R7, R8 and R9each is hydrogen, lower alkyl or phenyl; and R10 is loweralkyl or phenyl.They are useful as antiinflammatory agents and centralnervous system depressants. In addition, this type of com-pound increases the intracellular concentration of adenosine-3', 5'-cyclic -monophosphate.