AMIDE DERIVATIVES OF VLB, LEUROSIDINE, LEUROCRISTINE AND RELATED DIMERIC ALKALOID

摘要

AbstractThe invention relates to a process for preparingnovel dimeric alkaloid derivatives of vinblastine, vin-cadioline and leurocolombine by reacting vinblastine,vincadioline or leurocolombine with an amine and, ifdesired, reacting the resulting compound with a nitrosatingagent and an amine.