首页> 外国专利> method for the preparation of a pharmaceutical or veterinary preparationthat can be used for the treatment of arrhythmia and manufactured pharmaceutical application objects and work method for preparation of a dialkylaminoalkoxy - benzoylgroep substituted heterocyclic compounds and the zuuradditiezouten thereof.

method for the preparation of a pharmaceutical or veterinary preparationthat can be used for the treatment of arrhythmia and manufactured pharmaceutical application objects and work method for preparation of a dialkylaminoalkoxy - benzoylgroep substituted heterocyclic compounds and the zuuradditiezouten thereof.

机译:可以用于治疗心律不齐的药物或兽用制剂的制备方法以及所制得的药物应用对象,以及制备二烷基氨基烷氧基-苯甲酰基基团取代的杂环化合物及其zuuradditiezouten的工作方法。

摘要

Novel indolizine derivatives of the general formula: IMAGE and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R1 and R2, which are different, represent a hydrogen atom or a group of the formula: IMAGE wherein R3 and R4+L, which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive.
机译:通式:的新型吲哚嗪衍生物及其药学上可接受的酸加成盐,其中R代表具有1至5个碳原子的支链或直链烷基,苯基,单氟,单-氯-或一溴-苯基,二氟-,二氯-或二溴-苯基,甲氧基-苯基或甲基-苯基,其在芳族部分上任选地被氟原子取代,氯或溴以及不同的R 1和R 2代表氢原子或下式的基团:其中R 3和R4 + L相同,各自代表氢原子或甲基,Am代表二甲基氨基,二乙基氨基,二正丙基氨基,二正丁基氨基,吗啉代,哌啶子基,吡咯烷基或4-甲基哌嗪子基团,并且n为2至6(含)范围内的整数。

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