PROCESS FOR THE REARRANGEMENT OF 10,11-EPOXY-10,11- DIHYDRO-5H-DIBENZ¬B,FAZEPINE-5-CARBOXAMIDE TO 10- OXO-10,11-DIHYDRO-5H-DIBENZ¬B,FAZEPINE-5- CARBOXAMIDE

摘要

Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide to 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamideAbstractThe invention relates to a process for the rearrange-ment of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepine5-carboxamide of the formulato 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide of the formulawhich process comprises performing the rearrangement bymeans of a bromide or iodide of lithium, magnesium orcalcium in the dry form, or in the form of their knowncompounds with water (hydrates) or with organic substances,in a suitable solvent within a temperature range of20 - 120°C, preferably of 40 - 80°C.