Derivatives of 2-hydroxy-6,9-methano-11-amino-5,6,7,8,9,10-hexahydro-benzocyclooctene, process for their preparation and pharmaceutical compositions containing the same

摘要

The derivatives have the formulawherein R¹ and R2 are each independently selected from the group consisting of hydrogen; alkyl; alkenyl; cycloalkyl; cycloalkyl alkyl; cycloalkenyl; cycloalkenylalkyl; alkylcycloalkyl; alkenylcycloalkyl; alkylcycloalkenyl; phenyl; 5- and 6- membered heterocyclic wherein the heteroatom is nitrogen, oxygen, or sulfur; and said heterocyclic attached through C_1-2alkyl;R₃ and R₄ are each independently hydrogen or lower alkyl;R_s is hydrogen, alkyloxymethyl, alkylamino, aralkylamino, N-substituted carboxamido, or aralkyloxy methyl in which the N substituent is benzyl, phenylethyl, or phenylpropyl; andn is 1 or 2.