Oximes derived from erythromycin A, their preparation, their application in pharmaceuticals and pharmaceutical compositions containing them

摘要

The invention relates to derivatives 1 and their salts with acids A is an alkylene (1 to 6 carbons), R is alkyloxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio (at most 6 carbons), the sulfur being optionally oxidized, aryloxy, aralkyloxy, arylthio, aralkylthio, the sulfur being optionally oxidized, NR ₁ R ₂ , where R ₁ and R _{2 are} hydrogen, alkyl (1 to 6 carbons) or form a heterocycle, or R is a quaternary ammonium, a halogen, a 1,2, -epoxyethyl radical optionally substituted and optionally opened with a nucleophile, O-CO-B where B is alkyl, alkyloxy (1 to 6 carbons), aryl, aralkyl, aryloxy, aralkyloxy, or R is a free or protected formyl, a free carbonyl, esterified or salified, a thiocyanate , nitrile, acyl, carbamoyl, and R is hydrogen or acyl, their preparation from erythromycin or its 9-oxime, their use as antibiotic drugs and the compositions containing them.