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FUKUSOKANKAGOBUTSU FUKUSOKANKAGOBUTSUOGANJUSURUYAKUZAIOYOBIFUKUSOKANKAGOBUTSUNOSEIHO

机译:福寿馆鹿儿but福寿馆鹿儿Gan甘菊屋aku和福寿馆鹿儿but诚

摘要

Disclosed are new heterocyclic compounds, medicaments containing them (for oral or parenteral administration) and processes for the preparation and use of these heterocyclic compounds and medicaments. The new compounds which particularly act as inhibitors of blood platelet aggregation and as blood pressure lowering agents correspond to the general formula IMAGE (I) wherein R1 is hydrogen, a cation or the residue of an alcohol, R2 represents hydrogen or methyl, A is a member of the group consisting of the radicals -CH2-CH2-, (trans)-CH=CH- and -C 3BOND C-, and wherein B represents an alkyl or a cycloalkyl radical. In these compounds the phenyl radical may be arranged with respect to the double bond in the E- and/or in the Z-configuration and at the carbon atom bearing the group R2 (and others) may exist RS- or S-configuration. The compounds of formula I are prepared in a manner known per se starting from derivatives of 3 alpha ,5 alpha -dihydroxycyclopentane-1 alpha -acetaldehyde gamma -lactol substituted accordingly and phosphonium salts of the formula IMAGE wherein R6 represents hydrogen or alkyl and wherein Hal is chlorine, bromine or iodine.
机译:公开了新的杂环化合物,包含它们的药物(用于口服或肠胃外给药)以及这些杂环化合物和药物的制备和使用方法。新的化合物特别可作为血小板聚集的抑制剂和降血压剂,它们对应于通式<图像>(I),其中R1是氢,阳离子或醇残基,R2代表氢或甲基,A R 3是基团-CH 2 -CH 2-,(反式)-CH = CH-和-C 3BOND C-组成的组的成员,其中B代表烷基或环烷基。在这些化合物中,苯基可以相对于双键排列成E-和/或Z-构型,并且在带有基团R 2(和其他基团)的碳原子上可以存在RS-或S-构型。式I化合物以本身已知的方式由相应地取代的3α,5α-二羟基环戊烷-1α-乙醛γ-内酯的衍生物和式的phospho盐(其中R6代表氢或烷基和其中Hal是氯,溴或碘。

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