use of hydroxypropylmethylcellulose for coating pharmaceutical active substance in the shell containing weichgelatine - buccalkapseln

摘要

The thermal and dimensional stability of soft gelatin capsules containing a pharmaceutically active agent incorporated in the gelatin is improved by coating the capsules with a film coating of a film-forming polymer which is soluble or swellable in water and soluble in organic solvents, e.g. cellulose esters, cellulose ethers, polyvinyl pyrrolidone, acrylate/methacrylate co-polymers, polyethylene glycols, and zein. The capsules have a small air bubble as the core, and are usually for chewing or sucking to provide a prolonged local oral release of the active agent. The film coating may be applied by spraying on a solution of the polymer in organic solvent, and then drying the coating.