Substituted 4,5-dihydro-6-4-(1H-imidazol-1-yl)phenyl-3(2H)- pyridazinones and 6-4-(1H-imidazol-1-yl)phenyl-3(2H)-pyridazinones

摘要

Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-phenyl]-3(2H)- pyridazinone compounds and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)- pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic agents.PPSaid compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted -oxo- benzenebutanoic acids with suitably substituted hydrazines to provide 4,5- dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones which are dehydrogenated to 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones. P PBoth the intermediate 4,5-dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3(2H)-pyridazinones and the 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)- pyridazinones are useful as cardiotonic agents.