PURPOSE:The titled remedy, containing a substituted indoline as an active constituent, capable of exhibiting a high antimicrobial activity against fungi without irritation with low toxicity, and effective for treating superficial mycosis, e.g. trichophytosis, etc. CONSTITUTION:A remedy for superficial mycosis containing a substituted indoline of formulaI(R is H, halogen or nitro) as an active constituent. In formulating the remedy, one or more compounds of the active constituent in the form of fine powder may be applied to the affected part, and usually dissolved or dispersed in a liquid carrier, e.g. an alcohol such as methyl alcohol or ethyl alcohol, to give an alcoholic agent or lotion or incorporated with a solid carrier, e.g. vaseline or white ointment or a hydrophobic oily base, e.g. the silicone type, to give an ointment for application. The active constituent of the above-mentioned formula is synthesized by reacting a substituted indoline compound of formula II with 2-chloroacetyl chloride in the presence of an organic solvent and a base.
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