the inophorese and intermediate for contact solution for the treatment of chronic pain syndromes

摘要

A method of treating chronic pain is disclosed which comprises the step of topically administering to the skin of a human patient, 1 to 100 mu g/cm2 of body surface of a compound of the Formula (I) IMAGE (I) in which R is -CH3 or -CHO R1 is methoxy or amino; R2 is hydrogen, hydroxyl or acetoxy; R3 is hydrogen or ethyl; R4 and R5 together form a valency bond or an epoxy bridge, or R4 is hydroxy or ethyl; and R5 is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.