4.5 - dihydro - 6 - (substituted) - 1h-imidazol-4-yl - or - 5 - yl) - 3 (2h) - pyridazinoner and 6 - (substituted) - 1h-imidazol-4-yl or - 5 - yl) - 3 (2h) - pyridazinoner and syreadditionssalte thereofmethod for their manufacture and their use

摘要

4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones 6-[(substituted)-1H- imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents. The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate gamma -oxo-imidazolebutanoic acid with a suitably substituted hydrazine to provide 4,5-dihydro-6-(substituted)imidazolyl-3(2H)-pyridazinones which are oxidized to 6-(substituted)imidazolyl-3(2H)-pyridazinones.