NEW DERIVATIVES OF 6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO(4,5,L-J-K)(1)-BENZAZEPIN-2(1H)-ONE,THEIR SALTS,THEIR PREPARATION,THEIR APPLICATION AS MEDICAMENTS,AND THE COMPOSITIONS CONTAINING THEM

摘要

Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,l-j-k][1]-benzazepin- 2-(1H)-one derivatives of the formula IMAGE wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally substituted with a hydroxyl, aryl and aryloxy of 6 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms optionally interrupted with a heteroatom optionally substituted with alkyl of 1 to 4 carbon atoms and the wavy lines indicates that the 7-OH and 6-amino have the trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anti-hypertensive and hypotensive activity and vasodilatatory activity and their preparation.