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Epoxypregnadienes, hydroxypregnatrienes, process for their preparation and process for their conversion to precursors of useful anti-inflammatory agents
Epoxypregnadienes, hydroxypregnatrienes, process for their preparation and process for their conversion to precursors of useful anti-inflammatory agents
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机译:环氧孕二烯,羟基孕三烯,其制备方法及其转化为有用的抗炎剂前体的方法
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摘要
21-Hydroxypregna-1,4,17(20)- trien- 3-one 21- acylates are converted to novel 17a, 20a-epoxypregna-1,4- dien-3-one 21-acylates (I) using a peracid, compounds 1 are converted to novel 21-hydroxypregna-1,4,16- trien-3-one 21-acylates (II) with a hydrogen halide, and compounds II are converted to 20, 21-dihydroxypregna-1,4,16- trien-3-ones (III) by hydrolysis. Compounds III are useful intermediates in the production of anti-inflammatory agents.
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