首页> 外国专利> 3,4-Di:phenyl 4H-1,2,4-triazole analgesics - e.g. 3-ethyl-4-4 methoxy-phenyl 5-4-di:methylamino-phenyl-4H-1,2,4-triazole

3,4-Di:phenyl 4H-1,2,4-triazole analgesics - e.g. 3-ethyl-4-4 methoxy-phenyl 5-4-di:methylamino-phenyl-4H-1,2,4-triazole

机译:3,4-二:苯基4H-1,2,4-三唑镇痛药-例如3-乙基-4-4甲氧基-苯基5-4-二:甲基氨基-苯基-4H-1,2,4-三唑

摘要

3-R-4-R3R4 -phenyl-5-R1,R2-phenyl -4H-1,2,4-triazole derivs. of formula (I) and their acid addn. salts are claimed in the parent patent (FR2488891 17865E/10). The present patent of addn. claims the specific cpds. defined below (I) where R2, R4 are H except in (a) and R is ethyl; R1 is 4-methoxy and R3 is 4-(CH3)2N-, 4-NH2 or 4-chloro; (b) R is -CH2COOC2H5; R1 is 4-methoxy and R3 is H or 4-methoxy; (c) R is -CH2COOH; R1 4-methoxy and R3 is H; (d) R is isopropyl; R1 is 4-methoxy and R3 is 4-methoxy; (e) R is ethyl; R1,R2 are 3,4-methylenedioxy, 3,4-dimethoxy or 4-(CH3)2N and R3 is 4-methoxy; (f) R is ethyl; R1 is 4-hydroxy and R3 is 4-hydroxy or H; (g) R is ethyl; R1 is 4-(CH3)2N- and R3 is 4-nitro or 4-(CH3)2N; (h) R is methyl and R1,R3 are H and (i) R,R3 are H and R1 is 4-(CH3)2N. (B) Intermediates of formula W-CO-NH-NH-CO-R (II) and (IV) are specifically claimed (where (a) W is ethyl and R is 4-chlorophenyl, 3,4-methylenedioxy-phenyl or 3,4-dimethoxyphenyl or (b) W is isopropyl and R is 4-methoxy-phenyl. Analgesics useful for treating nerve, muscle or joint pain, toothache, migraine, rheumatic troubles etc. Admin. may be by enteral, parenteral or topical routes e.g. 50mg-2g daily p.o.
机译:3-R-4-R3R4-苯基-5-R1,R2-苯基-4H-1,2,4-三唑衍生物。式(I)的化合物及其酸加成。母体专利(FR2488891 17865E / 10)要求保护盐。 addn的当前专利。声明特定的cpds。在以下(I)中定义,其中R 2,R 4为H,除了(a)中,R为乙基; R1为4-甲氧基,R3为4-(CH3)2N-,4-NH2或4-氯; (b)R为-CH2COOC2H5; R1是4-甲氧基,R3是H或4-甲氧基; (c)R为-CH 2 COOH; R1为4-甲氧基,R3为H; (d)R为异丙基; R1为4-甲氧基,R3为4-甲氧基; (e)R为乙基; R1,R2是3,4-亚甲二氧基,3,4-二甲氧基或4-(CH3)2N,R3是4-甲氧基。 (f)R为乙基; R1为4-羟基,R3为4-羟基或H; (g)R为乙基; R1为4-(CH3)2N-,R3为4-硝基或4-(CH3)2N; (h)R为甲基且R 1,R 3为H和(i)R 1,R 3为H且R 1为4-(CH 3)2N。 (B)具有化学式W-CO-NH-NH-CO-R的中间体特别要求保护(II)和(IV)(其中(a)W为乙基且R为4-氯苯基,3,4-亚甲基二氧苯基或3,4-二甲氧基苯基或(b)W为异丙基,R为4-甲氧基苯基。用于治疗神经,肌肉或关节疼痛,牙痛,偏头痛,风湿病等的止痛药。可以通过肠内,肠胃外或局部给药路线,例如每天口服50mg-2g

著录项

  • 公开/公告号FR2512022B2

    专利类型

  • 公开/公告日1984-02-17

    原文格式PDF

  • 申请/专利权人 ROUSSEL UCLAF;

    申请/专利号FR19810016439

  • 发明设计人

    申请日1981-08-28

  • 分类号C07D249/08;A61K31/41;

  • 国家 FR

  • 入库时间 2022-08-22 08:45:39

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