New anticancer 4:epi:doxorubicin 14:ester(s) - prepd. by brominating 4:epi:daunorubicin and treating the 14:bromo compound with an acid salt

摘要

4'-Epidoxorubicin 14-esters of formula (I) are new. In (I), R = acyl group derived from one of the following acids: mono- or di-carboxylic aliphatic, aromatic, cycloaliphatic, araliphatic, or heterocyclic, which may contain up to 20C atoms and may be substituted by any of the following: halogens, OH, alkyl, alkoxy, amino, mono- or di-alkyl amino, nitro, alkyl or aryl carbonic acid, carbamic acid, alkyl carbamic acid, or sulphonic acid. - Specifically OR = acetate, octanoate, benzoate, or nicotinate.