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NOUVEAUX DERIVES DE LA FURO-(3,4-C)-PYRIDINE SUBSTITUES EN POSITION 6,UN PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS THERAPEUTIQUES A BASE DE CES DERIVES
NOUVEAUX DERIVES DE LA FURO-(3,4-C)-PYRIDINE SUBSTITUES EN POSITION 6,UN PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS THERAPEUTIQUES A BASE DE CES DERIVES
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机译:位置6取代的呋喃-(3,4-C)-吡啶的新衍生物,基于这些衍生物的制备和治疗组合物的过程
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摘要
This invention relates to new 1,3-dihydro-6-(1-hydroxy-2-dimethylaminomethyl-allyl)-7-hydroxy-furo-( 3,4-c)-pyridine derivatives of the general formula: IMAGE wherein, each of A1 and A2 independently, represents various substituents, to a process for the preparation of these compounds comprising reacting a 6-formyl-7-benzyloxy-furo-(3,4-c)-pyridine derivative of the general formula II IMAGE II with 1-dimethylaminomethyl-vinylmagnesium bromide at the boil, in a non polar solvent and hydrolyzing the 7-benzyloxy group and to a therapeutic composition of matter, comprising as an essential ingredient therein, at least one of these compounds. The compounds according to the invention are of interest for their therapeutic activity, principally as anti-depressive agents.
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