Process for preparing substituted pregn 18 - 4 Jan 3, 20 and dionas specific compounds 18 and etinilpregn - vinilidenopregn eno - 3 - 4 - 20 - dione

摘要

Process for preparing substituted pregn 18 - 4 Jan - dionas 3.20 and specific compounds 18 and vinilidenopregn etinilpregn - - 4 - - - eno 3,20 Dione.Is to react 3,3,20,20 - bis (etilenodioxi0pregn - 5 - - 18 - etinilmagnesio bromide, followed by removal of the ketal Protecting Groups by Treatment with acid, P - toluenosulfonico in acetone to obtain 18 - ethinyl - 18 - hidroxipregn - 5 Jan - 3,20 Dione.Pharmaceutically used for the treatment of hypertension, hypokalemia, hyperaldosteronism, alkalosis, Muscle weakness, polyuria and polydipsia.