Xanthine deriv. (I) [R1=hydrogen, C1-5 alkyl; R2=C1-6 alkyl; R3=hydrogen, C1-5 alkyl, hydroxy alkyl; R4= -CH-ph,-H2C-CH=CH-ph, (ph=phenyl); Z=methylene, C2-5 alkyl; A=amino residue! is prepd. for use as an inhibitor of phosphodiesterase. Halo compd. (II) [Hal=Cl, Br is condensed with amino compd., HAR4, to give the compd. (I). The reaction solvent is methanol, ethanol, propanol or butanol. This solvent contains sodium carbonate. The reaction temp. is 64-130C.
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机译：黄嘌呤衍生物。 （I）[R 1 ＝氢，C 1-5烷基; R2 = C1-6烷基; R 3 ＝氢，C 1-5烷基，羟烷基; R4 = -CH-ph，-H2C-CH = CH-ph，（ph =苯基）; Z =亚甲基，C2-5烷基; A =氨基残基！准备好了。用作磷酸二酯酶的抑制剂。光晕补偿。 （II）[Hal ＝ Cl，Br与氨基化合物HA4缩合，得到化合物。 （一世）。反应溶剂是甲醇，乙醇，丙醇或丁醇。该溶剂包含碳酸钠。反应温度是64-130C。
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