STABILIZATION OF CREATINE KINASE (CK) AND ITS APPLICATION AS A REFERENCE STANDARD

摘要

The enzyme creatine kinase (CK) is not very stable and there are problems in providing CK-containing standards for use in analysis of biological fluids containing CK. The present invention provides a stable form of CK, being a mixed disulfide or dithiosulfonate of CK which can be stored (e.g. in lyophilized form) in admixture with serum or proteins and can be converted into a standard reference sample by mixture with a thioactivating agent.