SUBSTITUTED 3,5-DIAMINO-1,2,4-OXADIAZOLES AND 3,5-DIAMINO-1,2,4-THIADIAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Compounds of the formula IMAGE (I) wherein R1 is hydrogen, halogen, or alkyl, R2 is halogen or alkyl, R3 is hydrogen, acyl, or saturated or unsaturated alkyl, R4 and R5 are individually hydrogen, or alkyl, wherein all alkyl and acyl groups are branched or straight-chain and each contains 1 to 4 carbon atoms, X is oxygen, nitrogen, or sulfur, Y is oxygen or nitrogen, and -X-Y- is -O-N-, -N-O-, or -S-N-, or salts of the above, with certain exceptions. Methods of preparation of the compounds, as well as their use as anti-hypertensives are also disclosed.