Method for preparing (2 - oxo - - One, two, three, Six tetrahidroimida zo (2,1-b) quinazolinil) - oxialquilamidas

摘要

Procedure for obtaining (2 - oxo - 2.1 - One, two, three, Six tetrahidroimidazo bquinazolinil) - oxialquilamidas and their physiologically compatible salts of formula (i), in which R1 and R5, and z can be several types of Radicals; and M and N is 1 to 6.Involves the reaction of a compound of formula (ii), in which z is lower alkoxy and the other symbols have the same meaning as in formula (i), with a strong base such as Sodium hydroxide or Potassium concentration between 1 and N 6n, at a temperature between 0jc and 50jc.These compounds have pharmacological applications to inhibit the activity and to inhibit cyclic fosfodiestarasa heart failure and the development of tumors.