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METHOD FOR PREPARING ULTRAFINE PARTICLE OF ORGANIC COMPOUND

机译:一种有机化合物超细颗粒的制备方法

摘要

PURPOSE:To obtain ultrafine particles of an org. compound, especially, water-insoluble medicine, by evaporating the org. compound under heating in inert gas within a vacuum container and coagulating fine particles generated by collision on a cooled recovery means. CONSTITUTION:An org. compound (containing a high-molecular compound) having vapor pressure of a definite value or more is put in a heating apparatus 2 and, after a vacuum container 1 is brought to a predetermined vacuum degree, inert gas is introduced into the container 1 to adjust the pressure thereof to a definite value and the heating of the org. compound is started. The molecules of the org. compound evaporated by heating are scattered and collide with each other to be formed into ultrafine partcles which are, in turn, coagulated on a coolled aluminum foil 7 to be accumulated thereon. As mentioned above, by regulating the pressure of the inert gas, ultrafine particles with a particle size of about 500Angstrom -4mum can be obtained. If the obtained fine particles are prepared from water-insoluble medicine, the stable aqueous dispersion thereof can be obtained and, therefore, an injection liquid can be obtained. Further, said particles can be expected as the material of an org. semiconductor or a sensor.
机译:目的:获得组织的超细颗粒。通过蒸发有机化合物来合成化合物,尤其是水不溶性药物。在真空容器内的惰性气体中加热下,使化合物熔化,并在冷却的回收装置上凝结因碰撞而产生的细颗粒。宪法:一个组织。将具有一定值以上的蒸气压的化合物(含有高分子化合物)放入加热装置2,将真空容器1设为规定的真空度后,向容器1内导入惰性气体进行调整。将其压力确定为一定值并加热组织。复合物开始。组织的分子。加热蒸发的化合物分散并相互碰撞,形成超细颗粒,这些颗粒又凝结在冷却的铝箔7上,从而积聚在其上。如上所述,通过调节惰性气体的压力,可以获得粒径约为500埃-4μm的超细颗粒。如果由水不溶性药物制备获得的细颗粒,则可以获得其稳定的水分散体,因此,可以获得注射液。此外,可以期望所述颗粒作为组织的材料。半导体或传感器。

著录项

  • 公开/公告号JPS62106833A

    专利类型

  • 公开/公告日1987-05-18

    原文格式PDF

  • 申请/专利权人 RES DEV CORP OF JAPAN;TOYOTAMA HIDEKI;

    申请/专利号JP19860166533

  • 发明设计人 TOYOTAMA HIDEKI;

    申请日1986-07-15

  • 分类号B01J19/00;A61K9/14;B01D3/34;B01D7/00;B01J2/00;C08J3/12;G03G5/00;

  • 国家 JP

  • 入库时间 2022-08-22 07:28:30

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