METHOD AND APPARATUS FOR SUCCESSIVELY PREPARING AUTOMATIC INJECTION TYPE SYRINGE FOR VACUUM FREEZE DRYING MEDICINE ARRANGED IN AIRTIGHT TUBE

摘要

Process for the preparation in a series of self-injectable syringes characterized mainly by the fact that multiple seal tubes are placed vertically on an appropriate support, that a syringe body is placed vertically in each seal tube, that, into each tubular body thus arranged, a single dose of the medication in solution in a solvent is placed in each seal tube, above the syringe body, a plunger suspended by its pusher in a movable manner, at the lower end of a stopper which can adapt to the seal tube, so that said plunger is essentially in the axis of the syringe body and the lower end of said plunger is located above the upper end of the syringe body, with said stopper being held in a position so that said seal tube is not blocked or is not entirely blocked, to thus obtain an assembly constituting an open system in which the internal space, in the seal tubes and above said solution in the syringe bodies, is connected with the outside of the system, that the lyophilization operation is effected and, at this time, downward vertical pressure applied to the stoppers so that said stoppers completely block said seal tubes while said plungers, fastened to said stoppers, are introduced into the tubular bodies until the predetermined maximum insertion position is reached; a device and stopper for the implementation of said process.