NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVE AND SALT THEREOF, PRODUCTION THEREOF AND AGENT, ACTING ON CARDIOVASCULAR SYSTEM AND CONTAINING SAID COMPOUND AS ACTIVE CONSTITUENT

摘要

NEW MATERIAL:A 1,4-dihydropyridine derivative expressed by formula I (either one of R1 and R2 is H, and the other is nitro; R3 is alkoxycarbonyl R4 is alkoxycarbonyl, alkoxycarbonyl having nitrogen atom-containing heterocylclic ring or alkoxycarbonyl or alkyl having phosphorus atom-containing substituent group, R5 and R6 are alkyl or alkyl having phosphorus atom-containing substituent group, provided that R3 and R4 do not mean alkoxycarbonyl at the same time except when R6 means alkyl having phosphorus-atom containing substituent group) and a salt thereof. EXAMPLE:3-Dimethylphosphonylmethyl 5-methyl 1,4-dihydro-2,6-dimethyl-4-(2- nitrophenyl)-3,5-pyridinecarboxylate. USE:Useful as an agent for cardiovascular systems having slight cardiotonic action and great lasting property. PREPARATION:Compounds expressed by formulas II, III and IV are reacted to afford the aimed compound expressed by formula I.